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Hyperkeratosis lenticularis perstans
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Hyperkeratosis lenticularis perstans

Contributors: Reba Suri MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease, is a rare dermatosis of unknown etiology characterized by asymptomatic, small, erythematous to brown, hyperkeratotic papules distributed symmetrically on the distal extremities. Lesions are typically less than 5 mm in diameter, with a predilection for the dorsal surface of the feet and distal lower extremities, typically sparing the palms, soles, and mucous membranes. This chronic condition is more common in women and presents in the fourth to fifth decade of life.

Incidence and prevalence of HLP are difficult to assess given the limited number of cases reported in the literature, which may in part be due to its asymptomatic nature. Whether the condition is a disorder of keratinization or primarily inflammatory, and whether it is familial or sporadic, is still up for debate. Additionally, there is no consensus in regard to a particular trigger (predisposing medical condition or exposure) that has been consistently associated with the condition, but association with spirochetal infection, various malignancies, and endocrine disorders have been reported in isolated cases.

Codes

ICD10CM:
L85.9 – Epidermal thickening, unspecified

SNOMEDCT:
28488007 – Hyperkeratosis lenticularis perstans

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Last Reviewed:04/21/2021
Last Updated:04/21/2021
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Hyperkeratosis lenticularis perstans
Hyperkeratosis lenticularis perstans
Copyright © 2021 VisualDx®. All rights reserved.