ContentsSynopsisCodesDifferential Diagnosis & PitfallsBest TestsDrug Reaction DataReferences
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Contributors: Marilyn Augustine MD
Other Resources UpToDate PubMed


Abnormally high level of prolactin in the blood due to hypersecretion of prolactin from lactotroph cells in the pituitary gland due to physiologic or pathologic causes.

This hypersecretion may result from prolactin-secreting tumor (prolactinoma), pregnancy, medications (typically psychiatric), or a large pituitary tumor.

There is a predisposition in women.

Clinical presentation is variable. Female patients most commonly present with oligomenorrhea, amenorrhea, reduced libido, or infertility (resulting from prolactin suppression of gonadotropin-releasing hormone [GnRH]). Galactorrhea in females may occur as a result of the physiologic effect of prolactin on breast epithelial cells. Male patients most commonly present with loss of libido, visual impairments, or headache. Decreased serum testosterone levels and hypogonadism in males may occur due to a decrease in luteinizing hormone and follicle-stimulating hormone resulting from prolactin suppression of GnRH. In both male and female patients, a pituitary tumor may cause visual-field defects and headache.

Complications include osteoporosis, which may result from decreased gonadal steroid secretion.

Treatment is ultimately aimed at managing symptoms and reducing tumor size. Patients taking drugs that cause hyperprolactinemia should discontinue use, if possible. Thyroid hormone replacement may be suggested for patients with hypothyroidism.

For more information, see OMIM.


E22.1 – Hyperprolactinemia

237662005  – Hyperprolactinemia

Differential Diagnosis & Pitfalls

  • Pregnancy or breastfeeding can result in physiologically normal elevated prolactin levels.
  • Macroprolactin can result in elevated prolactin levels without any clinical abnormality. The laboratory can precipitate macroprolactin prior to analysis for prolactin to avoid misdiagnosis.
  • Chronic renal failure can result in decreased clearance of prolactin and increased secretion of prolactin.
  • Chest wall injuries or nipple stimulation can transiently increase prolactin levels.

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated: 03/29/2017
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Hyperprolactinemia : Amenorrhea, Erectile dysfunction, Infertility, Oligomenorrhea
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