Hypervitaminosis D
Alerts and Notices
Synopsis
The primary complication of excess vitamin D levels is hypercalcemia. In the acute setting, hypercalcemia can result in nausea, emesis, altered mental status, weakness, polyuria, and polydipsia. Chronic vitamin D toxicity can result in the precipitation of kidney stones as well as bone demineralization and subsequent bone pain. Hypervitaminosis D in children can result in brain injury.
Codes
ICD10CM:E67.3 – Hypervitaminosis D
SNOMEDCT:
27712000 – Hypervitaminosis D
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
Differential diagnosis of hypercalcemia:- Hyperparathyroidism
- Sarcoidosis
- Lung carcinoma
- Multiple myeloma
- Thiazide diuretics
- Lymphoma
- Tuberculosis
- Coccidioidomycosis
- Familial hypocalciuric hypercalcemia
- Milk-alkali syndrome
- Chronic lithium use (see lithium nephropathy)
- Vitamin A toxicity
- Immobilization
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:12/12/2018
Last Updated:12/12/2018
Last Updated:12/12/2018