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Hypoparathyroidism in Adult
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Hypoparathyroidism in Adult

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Contributors: Casey Silver BA, Catherine Moore MD, Michael W. Winter MD
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Synopsis

Hypoparathyroidism is a disorder defined by decreased parathyroid hormone (PTH) production. Causes include surgical removal or damage during head and neck surgery and autoimmune destruction of the parathyroid glands. Acute clinical manifestations are mainly related to hypocalcemia and include muscle cramps that may progress to spasms, xerosis and brittle nails, numbness and tingling of the extremities or area around the mouth, and confusion or depression. Chronic hypoparathyroidism is associated with basal ganglia calcification, ocular disease, and skeletal and dental abnormalities.

Codes

ICD10CM:
E20.9 – Hypoparathyroidism

SNOMEDCT:
36976004 – Hypoparathyroidism

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Low PTH and low calcium can also be seen in hypomagnesemia or in patients with an activating mutation of the calcium-sensing receptor (CaSR) associated with autosomal dominant hypocalcemia.
  • Kidney disease, vitamin D deficiency, and pancreatitis can all cause hypocalcemia, but PTH will be elevated, distinguishing these diagnoses from hypoparathyroidism.

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 01/14/2019
Last Updated: 03/04/2019
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Hypoparathyroidism in Adult
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Hypoparathyroidism : Hoarseness, Irritability, Personality changes, Respiratory alkalosis, Muscle cramp, Diaphoresis, Myalgia, Paresthesias, Ca decreased
Clinical image of Hypoparathyroidism
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