Idiopathic gestational thrombocytopenia
Gestational thrombocytopenia is characterized by onset in the second or third trimester of isolated thrombocytopenia with steady (not precipitous) decrease in platelet count as the end of pregnancy approaches. This is most likely to be identified in the course of routine third trimester lab evaluation in as many as 5% of pregnant patients.
While the platelet count is depressed in affected individuals, this does not increase maternal or neonatal risks for bleeding complications. This condition spontaneously resolves after delivery.
O99.89 – Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
128090002 – Benign gestational thrombocytopenia
- Primary immune thrombocytopenia – This disease may coincide with pregnancy including first notation during pregnancy. Especially consider if low platelets have been noted pregestationally. Antiplatelet assays exist but do not provide ability to differentiate from gestational thrombocytopenia.
- Preeclampsia spectrum disorders – More likely to demonstrate transaminitis, increased creatinine, and/or hypertension in addition to thrombocytopenia.
- Thrombotic thrombocytopenia
- Liver disease
- Bone marrow disorders
- Disseminated intravascular coagulation (DIC)
- Drug-induced thrombocytopenia (see heparin-induced thrombocytopenia)
- Hereditary thrombocytopenias