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Idiopathic guttate hypomelanosis
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Idiopathic guttate hypomelanosis

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Contributors: Nkem Ugonabo MD, MPH, Alexis Perkins MD, Nikki Levin MD, Susan Burgin MD
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Synopsis

Idiopathic guttate hypomelanosis (IGH) is a common acquired condition, characterized by scattered 3- to 5-mm hypopigmented macules occurring on chronically sun-exposed skin. IGH typically occurs in middle-aged individuals with photodamage and increases in incidence with age and continued sun exposure.

While the exact cause is unknown, IGH has been hypothesized to be ultraviolet (UV) induced. Other contributing factors that have been suggested include aging, trauma, genetic factors, and autoimmunity.

IGH occurs in all skin types, and it appears more prominent in individuals with darker skin. No spontaneous repigmentation has been observed.

Codes

ICD10CM:
L81.9 – Disorder of pigmentation, unspecified

SNOMEDCT:
1717003 – Idiopathic guttate hypomelanosis

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Hypopigmented flat warts – These are perceptibly raised.
  • Hypopigmented seborrheic keratoses – Also perceptibly raised.
  • Tinea versicolor – Typically scaly and limited to the upper trunk and shoulder.
  • Pityriasis alba – Usually seen in atopic children; lesions are ill-defined.
  • Pityriasis lichenoides chronica (PLC) – Usually seen in a younger patient population than IGH and found on sun-protected skin; in young patients with dark skin phototypes, PLC may present as hypopigmented macules, and PLC may resolve with guttate leukoderma.
  • Leukodermic macules of Darier disease.
  • Postinflammatory hypopigmentation – Can be distinguished by preceding history of dermatitis.
  • Vitiligo – Lesions are depigmented, often acral, and coalesce to form larger depigmented patches.
  • Leukoderma punctata – 0.5- to 1.5-mm achromic macules that follow psoralen plus UVA (PUVA) or UVB therapy.
  • Lichen sclerosus – Shows a "tissue paper" atrophic appearance with telangiectasia; not confined to sun-exposed skin.
  • Atrophie blanche – Favors the distal shins and ankles but is usually atrophic and surrounded by telangiectasia.

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed: 03/19/2020
Last Updated: 03/20/2020
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Idiopathic guttate hypomelanosis
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Idiopathic guttate hypomelanosis : White color, Hypopigmented macules, Arms, Legs
Clinical image of Idiopathic guttate hypomelanosis
Numerous hypopigmented macules on the leg.
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