IgA nephropathy
Alerts and Notices
Synopsis

Patients may present in any of the following ways:
- Recurrent hematuria following viral pharyngeal or gastrointestinal tract infections
- Asymptomatic detection of hematuria and proteinuria on routine screening
- Rapidly progressive disease with associated edema, hypertension, hematuria, and renal insufficiency
Codes
ICD10CM:N02.8 – IgA nephropathy
SNOMEDCT:
236407003 – Immunoglobulin A nephropathy
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Post-streptococcal glomerulonephritis – Would usually be associated with history of group A streptococcal infection rather than viral infection.
- Staphylococcus-associated glomerulonephritis – Would usually be associated with staphylococcus infection rather than viral infection.
- Thin basement membrane nephropathy – Usually associated with family history.
- C3 glomerulopathy – Associated with elevated C3 levels.
- Hemolytic uremic syndrome – Often presents with bacterial gastrointestinal tract infection and diarrhea.
- Alport syndrome – Presents with hematuria, sensorineural hearing loss, vision problems, and family history.
- Goodpasture disease (anti-glomerular basement membrane antibody disease) – Presents with hemoptysis.
- Granulomatosis with polyangiitis (Wegener granulomatosis) – Presents with chronic sinusitis and cough, c-ANCA associated, patients in remission may develop IgA nephropathy.
- Microscopic polyangiitis – Presents with purpura and cough, p-ANCA associated.
- Eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome) – Presents with asthma and sinusitis, p-ANCA associated.
- Membranoproliferative glomerulonephritis – Associated with hepatitis B, hepatitis C, or low levels of C3.
- Systemic lupus erythematosus nephritis
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:01/07/2019
Last Updated:12/06/2021
Last Updated:12/06/2021