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IgA nephropathy
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IgA nephropathy

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Contributors: Shea A. Nagle BA, Christine Osborne MD, Catherine Moore MD, Abhijeet Waghray MD
Other Resources UpToDate PubMed

Synopsis

Immunoglobulin A (IgA) nephropathy develops secondary to mesangial deposition of IgA and is a common primary cause of glomerulonephritis. Peak age of presentation is in the 2nd and 3rd decade, although patients may present at any age. The disease is more common in males than in females, with the greatest frequency in individuals of Northern European or Asian descent. There is also an increased risk of IgA nephropathy in patients with celiac disease.

Patients may present in any of the following ways:
  • Recurrent hematuria following viral pharyngeal or gastrointestinal tract infections
  • Asymptomatic detection of hematuria and proteinuria on routine screening
  • Rapidly progressive disease with associated edema, hypertension, hematuria, and renal insufficiency
In children, it may present with IgA vasculitis (formerly Henoch-Schönlein purpura) after a viral infection.

Codes

ICD10CM:
N02.8 – IgA nephropathy

SNOMEDCT:
236407003 – Immunoglobulin A nephropathy

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 01/08/2019
Last Updated: 03/25/2019
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IgA nephropathy
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IgA nephropathy : Dark urine, Flank pain, Oliguria, Proteinuria, RBC casts, Recurring episodes or relapses, Gross hematuria
Copyright © 2019 VisualDx®. All rights reserved.