Acne presenting between 3 and 6 months of age is classified as infantile acne. Some authors consider infantile acne at the lower end of the age spectrum of juvenile acne, which presents at up to 24 months but with a median of 9 months. It is postulated that it is due to hormonal imbalances, an immature adrenal gland with elevated dehydroepiandrosterone (DHEA) and elevated luteinizing hormone (LH), often noted in infant males. Associated endocrine abnormalities and other virilizing signs are usually not seen. Infantile acne usually subsides after 1-2 years, although it may rarely persist into adolescence. Severe nodular forms may leave scars.
L70.4 – Infantile acne
49706007 – Infantile acne
Differential Diagnosis & Pitfalls
- Neonatal acne (benign cephalic pustulosis) – Appears around age 2 weeks and typically resolves by 3 months.
- Nevus comedonicus – Presents as a nonchanging and usually noninflammatory group of papules and comedones.
- Contact dermatitis – Typically consists of plaques rather than papules and pustules.
- Hyperimmunoglobulinemia E syndrome