Codes

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

• Peutz-Jeghers syndrome – Prominent lip, intraoral, and periorificial pigmentation is associated with hamartomatous gastrointestinal (GI) polyps and increased malignancy risk
• LEOPARD syndrome – Electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonary stenosis, abnormal genitalia, growth retardation, sensorineural deafness
• Carney complex – Cardiac and cutaneous myxomas, blue nevi, endocrine abnormalities
• Cronkhite-Canada syndrome – Nonfamilial GI polyposis syndrome with associated cutaneous hyperpigmented macules, onychodystrophy, and alopecia
• Generalized lentiginosis – Diffuse lentigines without systemic or mucosal involvement
• Laugier-Hunziker syndrome – May have oral and lip involvement; nails can be affected; no systemic involvement
• Centrofacial lentiginosis – Lentigines are found on the cheeks and nose in a butterfly distribution; association with bone abnormalities; dysraphia; endocrine, neurologic, and psychiatric disease
• Solar lentigines
• Dowling-Degos disease

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Management Pearls

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Therapy

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References

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