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Insulinoma
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Insulinoma

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Contributors: Casey Silver MD, Marilyn Augustine MD, Abhijeet Waghray MD
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Synopsis

Insulinoma : Blurred vision, Seizures, Chronic duration lasting years, Hypoglycemia, Diaphoresis, Tremor, Weight gain, Delirium/Confusion
An insulinoma is a rare insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. It is typically detected due to hyperinsulinemic hypoglycemia. The majority are benign. Common findings, besides hypoglycemia, include confusion, memory loss, diaphoresis, blurred vision, weight gain, weakness, dysarthria, tachycardia, palpitations, tremors, syncope, seizures, and coma. These symptoms typically develop for years before the affected patient is diagnosed. Risk factors include multiple endocrine neoplasia type 1 and von Hippel-Lindau syndrome.

Surgery is the treatment of choice. Some severe cases may require partial or complete pancreatectomy.

Codes

ICD10CM:
D13.7 – Benign neoplasm of endocrine pancreas

SNOMEDCT:
302822000 – Insulinoma

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Noninsulinoma pancreatogenous hypoglycemia syndrome
  • Exogenous insulin administration
  • Use of sulfonylureas or other hypoglycemic medications
  • Insulin autoimmune hypoglycemia
  • Familial hyperinsulinism (rare)
Many patients are initially misdiagnosed with a neurologic or psychiatric disorder.

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:05/08/2019
Last Updated:08/23/2022
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Insulinoma
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A medical illustration showing key findings of Insulinoma : Blurred vision, Seizures, Chronic duration lasting years, Hypoglycemia, Diaphoresis, Tremor, Weight gain, Delirium/Confusion
Copyright © 2023 VisualDx®. All rights reserved.