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Contributors: Marilyn Augustine MD
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A rare insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. It is typically detected due to hyperinsulinemic hypoglycemia. The majority are benign. Common findings besides hypoglycemia include confusion, memory loss, diaphoresis, blurred vision, weight gain, weakness, dysarthria, tachycardia, palpitations, tremors, syncope, seizures, and coma. These symptoms typically develop for years before the affected patient is diagnosed. Risk factors include multiple endocrine neoplasia type 1 and von Hippel-Lindau syndrome.

Most tumors require surgical excision. Some severe cases may require partial or complete pancreatectomy.


D13.7 – Benign neoplasm of endocrine pancreas

302822000  – Insulinoma

Differential Diagnosis & Pitfalls

  • Noninsulinoma pancreatogenous hypoglycemia syndrome
  • Exogenous insulin administration
  • Use of sulfonylureas or other hypoglycemic medications
  • Insulin autoimmune hypoglycemia
  • Familial hyperinsulinism (rare)

Best Tests

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Last Updated: 08/31/2016
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Insulinoma : Blurred vision, Delirium, Developed chronically lasting months to years, Hypoglycemia, No acute distress, Diaphoresis, Weight gain
Copyright © 2019 VisualDx®. All rights reserved.