Iododerma is a rare dermatological condition related to iodine administration. It has been associated with iodine as a treatment for thyroid disease, erythema nodosum, and sporotrichosis, potassium iodide in expectorants or multivitamins, amiodarone, topical povidone-iodine, oral iopanoic acid for cholecystography, and iodinated intravenous contrast (diatrizoate) for radiographic imaging.

Iododerma most commonly affects sebaceous areas (eg, face), but some cases involve the trunk, extremities, and mucous membranes. It has been associated with swelling of the major salivary glands. The cutaneous lesions of iododerma may include vesicular, pustular, acneiform, hemorrhagic, urticarial, fungating, suppurative, and ulcerative.

Decreased renal function in those receiving iodinated contrast media may increase risk of reaction, though iododerma has been reported in patients with normal renal function. Vegetating iododerma has been associated with polyarteritis nodosa and paraproteinemias such as multiple myeloma.

Though the pathogenesis of iododerma is not completely understood, it is thought to be related to a hypersensitivity reaction to iodine.