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Emergency: requires immediate attention
Kawasaki disease - External and Internal Eye
See also in: Overview,Anogenital,Oral Mucosal Lesion
Other Resources UpToDate PubMed
Emergency: requires immediate attention

Kawasaki disease - External and Internal Eye

See also in: Overview,Anogenital,Oral Mucosal Lesion
Contributors: Tyler Werbel MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Kawasaki disease (KD), or mucocutaneous lymph node syndrome, is a multisystem vasculitis that affects infants and children. The disease occurs primarily in children younger than 6 years. It is classically characterized by fever lasting at least 5 days (usually longer) plus 4 of the 5 following criteria:
  • Bilateral bulbar conjunctival injection without exudate
  • Oral mucosa changes: cracked lips, "strawberry tongue," or diffuse erythema of the mucosae
  • Changes in the extremities: erythema, induration, or periungual peeling
  • Exanthem
  • Cervical lymphadenopathy (greater than 1.5 cm diameter)
Eye findings are present in over 90% of cases of KD. The most common finding is a painless bilateral nonexudative bulbar conjunctivitis with sparing of the limbus. Anterior uveitis can also be seen in the first week of fever. Less commonly, patients will have subconjunctival hemorrhages or punctate keratitis. One case report demonstrated retinal vasculitis and retinal detachment.

Most individuals affected by KD follow a benign disease course. However, coronary artery aneurysms develop in 20%-25% of untreated patients. Treatment is aimed at decreasing the risk of developing coronary artery abnormalities and preventing complications from these abnormalities.

A multisystem inflammatory syndrome potentially linked to COVID-19 has been reported in children and young adults; clinical features include Kawasaki-like and toxic shock syndrome-like presentations.

For more information on Kawasaki disease, see OMIM.

Codes

ICD10CM:
M30.3 – Mucocutaneous lymph node syndrome [Kawasaki]

SNOMEDCT:
75053002 – Kawasaki disease

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Last Reviewed:08/08/2018
Last Updated:05/28/2020
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Emergency: requires immediate attention
Kawasaki disease - External and Internal Eye
See also in: Overview,Anogenital,Oral Mucosal Lesion
Kawasaki disease : Abdominal pain, Cervical lymphadenopathy, Diarrhea, Fever, Vomiting, Rash, Hand edema, Heart murmur, Irritability, Conjunctival injection, Strawberry tongue
Clinical image of Kawasaki disease
Erosions and hemorrhagic crusting on the lips.
Copyright © 2022 VisualDx®. All rights reserved.