Keratoacanthoma is a rapidly growing, well-differentiated neoplasm of squamous epithelium. Many consider keratoacanthomas to be a low-grade variant of squamous cell carcinoma (SCC). In contrast to classic SCCs, keratoacanthomas typically appear and grow rapidly over a few weeks and spontaneously involute and resolve within 6 months, leaving an atrophic scar. They are most commonly seen in individuals aged 60 years and older with light skin colors and a history of prolonged sun exposure. Men are more commonly affected than women. Risk factors include UV radiation, human papillomavirus infection, immunosuppression, and certain medications. Patients on immunosuppressant medications tend to have more persistent and chronic keratoacanthomas.