Keratoacanthoma - External and Internal Eye
A periocular keratoacanthoma appears and grows rapidly over the course of a few weeks to months. Lesions involving the eye may produce mechanical abnormalities, such as ectropion or ptosis, and, occasionally, may cause destructive changes. If left untreated, some keratoacanthomas spontaneously involute within 6 months, but they may resolve with scarring and destruction of ocular adnexa.
Risk factors include ultraviolet (UV) light exposure and immunosuppression. Skin injury may also be a predisposing factor, as there are many reports of keratoacanthomas developing in sites of previous trauma, in surgical scars, after laser resurfacing, and following radiation therapy. Foreign bodies, such as tattoo ink, have also been identified as risk factors for keratoacanthomas.
Many consider keratoacanthomas to be a low-grade variant of squamous cell carcinoma. Most will cause only local destruction. Due to the very thin skin of the eyelid, these lesions are particularly susceptible to extension into underlying stroma and even orbicularis oculi muscle. More invasive variants, with metastasis to draining lymph nodes or the cavernous sinus, have been reported.
L85.8 – Other specified epidermal thickening
254662007 – Keratoacanthoma
Differential Diagnosis & Pitfalls
Drug Reaction Data