In KE, annuli of erythema progress to air-filled superficial bullae that rupture to leave fine, expanding collarettes of scale. Bullae may coalesce and lead to desquamation of the entire volar surface; dorsal surfaces are less commonly involved.
While generally asymptomatic, KE can cause a mild, initial burning or tingling sensation and pain upon blister rupture. Chronically, thinning of the skin can cause local sensitivity. Involved surfaces are often associated with hyperhidrosis. Blistering is exacerbated by friction and moist, warm environments.
L26 – Exfoliative dermatitis
239065004 – Keratolysis exfoliativa
Differential Diagnosis & Pitfalls