ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences
Keystone virus infection
Print
Other Resources UpToDate PubMed

Keystone virus infection

Print Images (1)
Contributors: Tyler Werbel, Paritosh Prasad MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Keystone virus (genus Orthobunyavirus, family Peribunyaviridae) is a negative-sense single-stranded RNA virus that predominantly infects mammals, including rabbits, raccoons, squirrels, and white-tailed deer. It is transmitted by mosquitoes, particularly Aedes atlanticus. The virus was first isolated from mosquitoes in Keystone, Florida, where its name derives. It has subsequently been identified in animals and mosquitoes throughout the coastal southeastern United States, from the Chesapeake Bay to Texas.

Although studies conducted in the 1960s demonstrated that 19%-21% of humans living in the Tampa Bay area were seropositive for the virus, there has only been one confirmed case of clinical disease associated with Keystone virus infection. The patient was a 16-year-old man who presented in 2016 with a low-grade fever and diffuse nonpruritic skin rash. The rash started on his chest, progressively spread, and resolved within two days. It was exacerbated by heat and sunlight. He had no other symptoms. Although the authors of the case report admitted that they could not definitively prove causality, the data was suggestive. They concluded that many of the individuals that present with transient rash and fever in endemic regions could actually represent Keystone virus infections.

Codes

ICD10CM:
A92.8 – Other specified mosquito-borne viral fevers

SNOMEDCT:
61399004 – Keystone virus

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Reviewed: 08/08/2018
Last Updated: 09/06/2018
Copyright © 2019 VisualDx®. All rights reserved.
Keystone virus infection
Print 1 Images
Keystone virus infection : Fever, Mosquito exposure
Copyright © 2019 VisualDx®. All rights reserved.