The natural history of lentigo maligna is that of gradual, asymmetric, radial growth. The majority of lesions are > 6 mm, macular, and variably pigmented with ill-defined, irregular borders. Lentigo maligna has a particular predilection for the nose and cheeks.
Approximately 5% are thought to progress to lentigo maligna melanoma, although it may be several years before this vertical growth phase occurs.
Lentigo maligna and lentigo maligna melanoma have been associated with nonmelanoma skin cancers, Werner syndrome, oculocutaneous albinism, and xeroderma pigmentosa.
D03.9 – Melanoma in situ, unspecified
302836005 – Lentigo maligna
Differential Diagnosis & Pitfalls