Lipoatrophy in Adult
Localized lipoatrophy has been subcategorized into the following: annular, abdominal, semicircular, and postinjection. These subcategories aim to describe clinical presentation, with the exception of postinjection lipoatrophy. The cause of lipoatrophy in annular, abdominal, and semicircular categories is thought to be postinflammatory.
Injection site lipoatrophy can be associated with insulin, corticosteroids, and antibiotics, among others, and history is a key component of making this diagnosis. Lipoatrophy associated with HIV is thought to result from antiretroviral treatment, although the exact mechanism is unknown.
E88.1 – Lipodystrophy, not elsewhere classified
248315005 – Lipoatrophy
Differential Diagnosis & Pitfalls
- – Hyperpigmented or hypopigmented indurated plaques. Induration is a key clinical feature lacking in lipoatrophy, and biopsy of this condition is diagnostic with broadened compact collagen bundles in a square punch biopsy.
- of Pasini and Pierini – Blue to brown hyperpigmented atrophic plaques without induration that are often symmetric and bilateral. The transition from normal to involved skin is classically described as a "cliff drop." Symmetry of this disease can help diagnosis, as histology in this condition is often nonspecific.
- can result in fat loss.
Drug Reaction Data