Lipoblastoma is a term used to describe encapsulated, soft subcutaneous neoplasms of immature fat, while lipoblastomatosis is a term used to describe unencapsulated and more infiltrating lesions. They are tumors of infancy primarily affecting neonates and infants. Males are affected twice as often as females. The most common locations are the extremities, trunk, and face. Parents usually notice a soft, subcutaneous or deep, mobile, soft tissue mass that can range in size from 1-12 cm on the extremity of a neonate or infant. Lipoblastomas are easily treated by complete excision and rarely recur because they are encapsulated, but lipoblastomatosis has a higher incidence of recurrence given its diffuse nature.