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Löfgren syndrome
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Löfgren syndrome

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Contributors: Benjamin L. Mazer MD, MBA
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Synopsis

Löfgren syndrome is a constellation of symptoms that is nearly always suggestive of acute sarcoidosis. The primary symptoms are erythema nodosum and hilar lymphadenopathy. Arthritis, uveitis, and fever also frequently occur. Primary tuberculosis can rarely present with hilar lymphadenopathy and erythema nodosum. The simultaneous presence of all the typical features of Löfgren syndrome, however, is highly specific for sarcoidosis.

Löfgren syndrome predominantly occurs in female patients of Northern European descent. Unlike other manifestations of sarcoidosis, Löfgren syndrome usually resolves within 2 years and rarely relapses. NSAIDs are the typical treatment, with immunosuppression sometimes required.

Codes

ICD10CM:
D86.86 – Sarcoid arthropathy

SNOMEDCT:
238676008 – Lofgrens syndrome

Differential Diagnosis & Pitfalls

Differential diagnosis depends on presenting symptoms.

See erythema nodosum for a differential of skin findings, and also consider:
Hilar lymphadenopathy:
Arthritis:
Uveitis:

Best Tests

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References

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Last Updated: 05/27/2016
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Löfgren syndrome
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Löfgren syndrome : Fever, Hilar lymphadenopathy, Malaise, Migrating polyarthralgia, Arthralgia
Copyright © 2019 VisualDx®. All rights reserved.