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Malakoplakia
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Malakoplakia

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Synopsis

A rare, chronic granulomatous inflammatory condition associated with infections and presenting as soft mucosal plaques, nodules, or papules predominantly in the urinary tract but also in gastrointestinal organs. Affected areas may be pulmonary, central nervous system, genital, skin, neck, and tongue. Patients may be asymptomatic or present with nonspecific symptoms such as pain and fever, with additional findings depending on organ systems affected. May occur at any age, with median diagnosis at about age 50. More common in females. Rarely appears in children. May be associated with recurring urinary tract infections, chronic illness, and renal transplant, particularly in immunosuppressed patients.

Lesions are composed of periodic acid Schiff stain (PAS) positive histiocytes (von Hansemann cells) with Michaelis-Gutmann laminar inclusion bodies. Antibiotics are commonly used in treatment.

Codes

ICD10CM:
N32.89 – Other specified disorders of bladder

SNOMEDCT:
50707001 – Malakoplakia

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Last Updated: 01/18/2016
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Malakoplakia
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Malakoplakia : Diarrhea, Flank pain, Abdominal mass, Hematuria, Lower abdominal pain, Urinary frequency, Dysuria, BUN elevated
Copyright © 2019 VisualDx®. All rights reserved.