Monitoring core temperature during surgical use of inhaled anesthetics can identify early MH.
MH crisis can be treated by immediately stopping the triggering anesthetic, administering dantrolene, treating hyperkalemia (hyperventilating), and lowering body temperature. Failure to treat MH crisis immediately leads to severe organ damage and death.
A predisposition to MH crisis is associated with an autosomal dominant pattern of inheritance caused by mutations in RYR1 and CACNA1S genes. Genetic skeletal muscle receptor abnormalities allow excessive calcium accumulation in response to anesthetic agents. Central core disease, King-Denborough syndrome, and central nuclear myopathy are also conditions that predispose patients to MH crisis.
T88.3XXA – Malignant hyperthermia due to anesthesia, initial encounter
405501007 – Malignant Hyperthermia
Differential Diagnosis & Pitfalls
Drug Reaction Data