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Malignant teratoma in Adult
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Malignant teratoma in Adult

Contributors: Benjamin L. Mazer MD, MBA
Other Resources UpToDate PubMed


A malignant, or immature, teratoma is an uncommon germ cell tumor. Teratomas are derived from embryonal germ layers (endoderm, mesoderm, ectoderm). Immature teratomas are partly distinguished from the mature form by the presence of neuroectoderm. Teratomas usually present in the ovaries or testes, retroperitoneum, mediastinum, or central nervous system. Immature teratomas most often occur in people under 20 years of age.

Signs of malignant teratoma depend on the location of the tumor and are usually secondary to mass effect or compression. These tumors may secrete alpha-fetoprotein, but this is not diagnostic.

Malignant teratomas are treated with surgery and chemotherapy. Malignant teratomas discovered at even an advanced stage typically have a good survival rate.

A malignant teratoma may occur years after the primary tumor.


C62.90 – Malignant neoplasm of unspecified testis, unspecified whether descended or undescended

189847002 – Malignant teratoma

Differential Diagnosis & Pitfalls

Differential diagnosis depends on patient age and body location.


Best Tests

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Last Updated:05/20/2019
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