A Mallory-Weiss tear is an upper gastrointestinal (GI) bleed due to longitudinal tearing in the esophagus and stomach. This often results from protracted, forceful vomiting, although shear forces from coughing, convulsions, straining, blunt trauma, or an endoscopy can also cause mucosal tears. Patients with acute or chronic alcohol abuse have a propensity to develop Mallory-Weiss tears.
Patients with Mallory-Weiss tears present with hematemesis and/or melena, and often with either epigastric or back pain. Management involves initiation of IV proton pump inhibitors, hemodynamic stabilization (either IV fluids or red blood cell transfusions), and endoscopy, with timing dependent on hemodynamic compromise.
Pediatric Patient Considerations: While uncommon in the pediatric population, Mallory-Weiss syndrome can occur in children and may indicate an underlying bleeding condition.
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.