Mantle cell lymphoma
It is characterized by a CCND1 translocation, t(11;14)(q13;q32), in more than 95% of cases.
MCL makes up 3%-10% of non-Hodgkin lymphomas and occurs in older individuals (median age of 60-70 years) with a male predominance. Most patients present with advanced (stage III or IV) disease. Symptoms may include fatigue, fever, night sweats, unintentional weight loss, lymphadenopathy, hepatosplenomegaly, and/or abdominal discomfort.
C83.10 – Mantle cell lymphoma, unspecified site
443487006 – Mantle cell lymphoma
Differential Diagnosis & Pitfalls
- Other B-cell lymphomas – nodal marginal zone lymphoma, extranodal marginal zone lymphoma, splenic marginal zone lymphoma, chronic lymphocytic leukemia, follicular lymphoma, lymphoplasmacytic lymphoma
- Splenomegaly can occur with other hematologic disorders including leukemia and other myeloproliferative neoplasms, as well as nonmalignant causes (autoimmune or infection).
- Infectious mononucleosis (Epstein-Barr virus [EBV] infection)
- Other infectious lymphadenitis (eg, cat-scratch fever)
- Other systemic or indolent infections that present with B symptoms (eg, endocarditis, osteomyelitis, tuberculosis)
- Other cancers (carcinoma, melanoma, sarcoma)
Drug Reaction Data