Marburg filoviridae virus infection - Chem-Bio-Rad Suspicion
In 1967, the first identified cases of MFVI occurred in Marburg, Germany, among vaccine laboratory workers who came in contact with African green monkeys from Uganda. However, identification of the natural reservoir has been elusive, although non-human primates, rodents, and bats have all been suspected. Contact with the tissue of an infected animal has been implicated in some outbreaks. Person-to-person transmission has been documented and probably occurs through contact with bodily fluids, including those of the deceased or near-deceased when viral load is greatest.
After an incubation period of 2-14 days (usually 5-7 days), MFVI victims experience the sudden onset of high fever, chills, headache, extreme fatigue and weakness, myalgias, nausea, vomiting, abdominal pain, and diarrhea. A maculopapular rash (typically on the trunk) as well as pharyngitis, conjunctivitis, and/or a non-productive cough may occur. Five to seven days after onset, the disease may steadily progress to involve the well-known hemorrhagic manifestations (typically from the GI tract, mucous membranes, eyes, urinary tract, nose, gums, and venipuncture sites). Other advanced symptoms include jaundice, pancreatitis, anorexia, photophobia, delirium, blindness, renal insufficiency, liver dysfunction, shock, and multi-system organ failure. The mortality rate of naturally occurring Marburg is approximately 25%-90%, with most deaths occurring within 2 weeks.
There is no human vaccine currently available, but some successful non-human primate trials suggest that human vaccine development may eventually have positive results.
Recent visitors to central Africa, zookeepers, owners of exotic pets, and veterinarians are susceptible to contracting MFVI.
A98.3 – Marburg virus disease
77503002 – Marburg virus disease
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