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Metastatic melanoma
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Metastatic melanoma

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Contributors: Michael W. Winter MD, Carla Casulo MD
Other Resources UpToDate PubMed


Melanoma is a life-threatening malignancy of pigment-producing cells (melanocytes) that may arise from a previously existing pigmented lesion or develop de novo; prognosis is worse with increasing depth of invasion. Melanoma can spread from its primary site to another anatomic location. The most frequent sites of melanoma metastasis are the lymph nodes, lungs, liver, brain, and bones; other organs, including the heart, have been involved.


C43.9 – Malignant melanoma of skin, unspecified

443493003 –  Metastatic malignant melanoma

Differential Diagnosis & Pitfalls

Metastatic melanoma can behave similarly to any other metastatic solid tumor such as lung cancer, breast cancer, colon cancer, renal cancer, etc. Brain metastases occur frequently as well, which can also be seen with metastatic lung cancer or other cancers. The differential also includes squamous or basal cell cancer when visualized on the skin only.

Best Tests

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Last Updated: 04/23/2019
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Metastatic melanoma
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Metastatic melanoma : Bone pain, Regional lymphadenopathy, Well-defined solitary pulmonary nodule/mass, Hyperpigmented papules, Firm nodules
Clinical image of Metastatic melanoma
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