ContentsSynopsisCodesDifferential Diagnosis & PitfallsBest TestsReferencesView all Images (39)
Metastatic melanoma
Other Resources UpToDate PubMed

Metastatic melanoma

Contributors: Michael W. Winter MD, Carla Casulo MD
Other Resources UpToDate PubMed

Synopsis

Melanoma is a life-threatening malignancy of pigment-producing cells (melanocytes) that may arise from a previously existing pigmented lesion or develop de novo; prognosis is worse with increasing depth of invasion. Melanoma can metastasize to any organ of the body. The most frequent sites are skin / subcutaneous, lymph nodes, lungs, liver, and brain.

Codes

ICD10CM:
C43.9 – Malignant melanoma of skin, unspecified

SNOMEDCT:
443493003 –  Metastatic malignant melanoma

Differential Diagnosis & Pitfalls

Metastatic melanoma can behave similarly to any other metastatic solid tumor such as lung cancer, breast cancer, colon cancer, renal cancer, etc. Brain metastases occur frequently as well, which can also be seen with metastatic lung cancer or other cancers. The differential also includes squamous or basal cell cancer when visualized on the skin only.

Best Tests

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References

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Last Updated:07/21/2020
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Metastatic melanoma
Metastatic melanoma : Bone pain, Regional lymphadenopathy, Well-defined solitary pulmonary nodule/mass, Hyperpigmented papules, Firm nodules
Clinical image of Metastatic melanoma
A close-up of a cluster of black and deep gray papules, and background sun-damaged skin.
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