Microscopic colitis is more common in adults older than 60 years and has an incidence of approximately 8.6 cases per 100 000 person-years. Female patients are more likely to have collagenous colitis, but there is no clear sex predilection in lymphocytic colitis.
The most common symptom is a chronic, watery diarrhea. Hematochezia, melena, and bright red blood per rectum (BRBPR) are uncommon. Some patients will experience weight loss and malaise. Abdominal pain, cramps, bloating, nausea, and fecal incontinence have also been reported. Undiagnosed and untreated, symptoms from microscopic colitis are often continual, although they may not progressively worsen.
Patients with autoimmune diseases such as type 1 diabetes mellitus, celiac disease, and autoimmune thyroiditis are at increased risk of developing microscopic colitis. Additionally, smoking and many medications are associated with microscopic colitis.
K52.831 – Collagenous colitis
K52.832 – Lymphocytic colitis
K52.839 – Microscopic colitis, unspecified
235753003 – Microscopic colitis
- Celiac disease
- Infectious gastroenteritis
- Inflammatory bowel disease (see Crohn disease, ulcerative colitis)
- Bile acid diarrhea
- Carbohydrate malabsorption (ie, lactose intolerance, fructose intolerance, sorbitol intolerance)
- Irritable bowel syndrome, diarrheal-type
- Small intestinal bacterial overgrowth
- Pancreatic insufficiency
- Laxative abuse
- Carcinoid syndrome