Minocycline drug-induced pigmentation in Adult
The incidence seems highest in patients with conditions such as atopic dermatitis, acne vulgaris, rheumatoid arthritis, pemphigoid, and pemphigus.
Four types of hyperpigmentation have been described: types I–IV. Each type varies in distribution and histology. (For type details, refer to Look For section.)
Pediatric Patient Considerations:
Children aged younger than 9 years should not be on medications from the tetracycline family of antibiotics.
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter
110284009 – Drug-induced pigmentation
- Drug-induced pigmentation (antimalarials) – brown, gray-brown, blue-black, yellow, or yellow-green pigmentation may occur with use of more than 1 year; may affect the nail beds
- Drug-induced pigmentation, flagellate – bleomycin and other chemotherapy
- Drug-induced pigmentation, amiodarone – initially shows dusky-red erythema with eventual progression to a blue-gray pigmentation of sun-exposed areas
- Melasma (chloasma)
- Post-inflammatory hyperpigmentation has history of preceding inflammation.
- Fixed drug eruption
- Large plaque parapsoriasis
- Generalized hyperpigmentation is also seen in Addison disease, Cushing syndrome, scleroderma, Wilson disease, hemochromatosis, chronic renal failure, porphyria cutanea tarda, vitamin B12 deficiency, pellagra, ochronosis, Gaucher disease, and carcinoid syndrome.
- Erythema ab igne
- Ashy dermatosis (erythema dyschromicum perstans)
- Confluent and reticulated papillomatosis (Gougerot-Carteaud syndrome)
- Cutaneous T-cell lymphoma
- Human immunodeficiency virus (HIV)-infected patients and AIDS patients on zidovudine may develop brown macules on the oral mucosa or lips and longitudinal brown bands on nails.