Monoclonal gammopathy of undetermined significance
Several dermatoses are associated with MGUS including scleromyxedema, primary systemic amyloidosis, and normolipemic plane xanthomas. Additionally, erythema elevatum diutinum, subcorneal pustular dermatosis, scleredema, and acquired angioedema (C1 inhibitor deficiency) may have an underlying monoclonal gammopathy. Schnitzler syndrome and POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma, and skin changes and sclerotic bone changes) are rare syndromes that are seen in the setting of MGUS.
D47.2 – Monoclonal gammopathy
35601003 – Monoclonal gammopathy of undetermined significance
Differential Diagnosis & Pitfalls