Morton neuroma refers to neuropathic pain in the region of the metatarsus, most commonly between the third and fourth metatarsals, caused by interdigital nerve compression. It is not a true neuroma. Common signs and symptoms include numbness, hyperesthesia or paresthesia in the distal metatarsals, a sensation of a pebble in the shoe, and aching or burning foot pain radiating from the metatarsal heads to the third and fourth toes, which may be associated with high heels, tight shoes, and overpronation. Palpation of the area may cause tenderness. It is a common cause of forefoot pain in adults. Symptoms tend to improve when pressure is offloaded from the affected foot.

The condition is typically treated conservatively and rarely requires more invasive treatment with injections or surgical excision. Prognosis is good, but some patients may have recurrent symptoms or regrowth of neuromas following surgery.