Mucormycosis in Adult
Mucormycosis can cause serious life-threatening infections in compromised hosts. While rhinocerebral mucormycosis is the most common form of the disease, mucormycosis can involve the skin, pulmonary, renal, and gastrointestinal organs, or it can disseminate. The underlying risk factor can influence the clinical manifestation; rhinocerebral disease is common in people with diabetes, whereas patients with hematological malignancies or neutropenia usually have sinus and/or pulmonary disease and, more rarely, gastrointestinal disease. Though uncommon, in renal transplant patients, the primary location of infection when it does happen remains rhinocerebral and pulmonary, but up to 10% can involve the transplanted renal allograft.
The 5 major types of mucormycosis are:
- Rhino-orbital-cerebral disease – Patients present with unilateral facial pain, headaches, fever, nasal or sinus congestion and discharge, and black, necrotic ulcerations, usually involving the palate. Infection can erode locally and spread to the cavernous sinus, the internal carotid artery, and the brain. Orbital involvement can lead to orbital cellulitis, ophthalmoplegia, and multiple cranial nerve palsies, with a potential for permanent residual effects such as blindness and cranial nerve defects occurring up to 70% of the time. These patients may present with only a central retinal artery occlusion.
- Pulmonary disease – In the immunocompromised host, this can be insidiously and minimally symptomatic, often identified incidentally by chest CT or presenting with isolated fevers unresponsive to antibiotics. Some patients may develop cough, dyspnea, and unremitting fever despite broad-spectrum antibiotics. Hemoptysis occurs as a result of tissue necrosis and angio-invasion and, rarely, can be fatal. Physical examination findings are nonspecific and can include tachypnea, crackles, decreased breath sounds, and wheezing, though often the lung examination is normal.
- Cutaneous disease – This form of mucormycosis may be primary or secondary. Primary infection may be associated with direct inoculation from trauma, burns, and surgical wounds. The affected tissue becomes inflamed, followed by subsequent necrosis. Secondary cutaneous mucormycosis occurs from hematogenous spread.
- Gastrointestinal disease – This form is mainly seen in extreme cases of malnutrition or immunosuppression. It is believed to occur via direct ingestion of spores. Clinical findings may include abdominal pain, nausea, vomiting, gastrointestinal bleeding, fever, and change in bowel habits. It is the most common form of mucormycosis in newborns.
- Disseminated disease – This most commonly occurs following pulmonary mucormycosis, although it could be a result of any subtype. The brain is the most susceptible to infection, followed by the spleen, heart, skin, and other organs.
In patients with HIV, mucormycosis is rare, but when it does occur, it can do so without the typical predisposing factors. In patients with HIV / AIDS, mucormycosis tends to occur in those who use intravenous drugs, patients with prolonged and severe neutropenia, and individuals with very low CD4 counts. Systemic involvement can be severe and progress rapidly, or the disease can progress insidiously. Death frequently occurs. Mucormycosis may complicate previous bacterial infection.
In immunocompetent hosts, epidemic mucormycosis has been associated with penetrating and nonpenetrating trauma caused by natural disasters, for example, the tornado in Joplin, Missouri, in 2011. DNA analysis in that case showed an Apophysomyces trapeziformis species. In the wake of the COVID-19 pandemic, post-COVID-associated mucormycosis (predominantly pulmonary) has been reported with increasing frequency, particularly on the Indian subcontinent.
For discussion of diseases caused by fungi belonging to the order of Entomophthorales, see cutaneous basidiobolomycosis, disseminated basidiobolomycosis, and rhinofacial conidiobolomycosis.
B46.5 – Mucormycosis, unspecified
76627001 – Mucormycosis
- The differential of a lung nodule in an immunocompromised host includes nonstandard presentations of common bacteria (Staphylococcus aureus, Pseudomonas aeruginosa), Legionella micdadei, nocardiosis, actinomycosis, other fungal infections such as Aspergillus, Cryptococcus, endemic fungal infections such as histoplasmosis, blastomycosis, and coccidioidomycosis, as well as noninfectious etiologies such as neoplasms (eg, post-transplant lymphoproliferative disease [PTLD]).
- Ecthyma gangrenosum in patients who are immunocompromised.
- The clinical manifestations of mucormycosis are similar to that of other invasive fungi like Aspergillus, Fusarium, and Pseudallescheria spp. Mucor appears as broad, non-septate hyphae with branches occurring at right angles; rarely, septa may be seen. The other fungi have thinner, septate hyphae with frequent, acute-angled branching.
- Leishmaniasis (Old World and New World)
- Candida sepsis