Mucous membrane pemphigoid - Anogenital in
MMP is almost twice as common in females as it is in males, and it is seen most frequently in older individuals.
MMP affects the mucous membranes and, less commonly, the skin. The mouth is involved most often (ie, painful erosions and ulcers), followed by the conjunctiva (corneal inflammation and scarring, conjunctiva inflammation, trichiasis, ectropion, symblepharon, ankyloblepharon, and blindness). Skin, nasal, laryngeal, pharyngeal, and esophageal mucosal surfaces can also be affected, leading to epistaxis, hoarseness, or dysphagia, respectively.
Uncircumcised men may experience phimosis secondary to scarring. Perianal disease may present as perianal erythema and scarring.
Cutaneous disease, when present, most frequently accompanies mucous membrane disease. Occasionally, cutaneous blistering and scarring dominate the clinical picture (so-called Brunsting-Perry variant).
In a 2022 study, malignancies, especially solid organ tumors, were reported in up to 13.8% of patients. These include lung carcinoma, prostate cancer, penile cancer, breast cancer, and non-Hodgkin lymphoma. The malignancy rate was higher when autoantibodies against laminin-332 were found.
L12.1 – Cicatricial pemphigoid
34250006 – Cicatricial pemphigoid
- Bullous pemphigoid, most frequently seen in the elderly, presents with nonfragile blisters.
- Pemphigus vulgaris presents with flaccid, fragile blisters.
- Erythema multiforme – These lesions are round, light-red spots with concentric zones and, at times, blisters and exudates.
- Lichen sclerosus lacks the vesicles and erosions seen in MMP.
- Hailey-Hailey disease occurs primarily in body folds such as the inguinal fold.
- Genital aphthous ulcers
- Behçet disease
- Zoon balanitis – Orange-brown glistering plaques are seen.