Necrotizing fasciitis in Adult
Necrotizing fasciitis can occur without a clear portal of entry, although predisposing risk factors include major penetrating trauma (eg, crush injury, deep penetrating wound), minor nonpenetrating trauma (eg, muscle strain, sprain, or contusion), and breaches in the skin and mucosa (eg, lacerations, varicella vesicles, insect bites, injection drug use, hemorrhoids, episiotomies, and other surgical wounds). Vibrio vulnificus is associated with necrotizing fasciitis infections in cirrhotic patients with exposure to ingestion of raw oysters and with exposure of lacerations to salt water. Aeromonas hydrophila is part of the Vibrionaceae family and can cause necrotizing fasciitis in both immunocompromised and immunocompetent patients. Unlike V vulnificus sepsis, where exposure is usually to seawater, in A hydrophila infection, contact with brackish water, soil, wood, or dirty ditches is typically the common exposure. Infections can follow any trauma, fracture, or injury where there was exposure to fresh water. Infection has also occurred in the setting of debris or floodwater after a hurricane. Both V vulnificus and Aeromonas infections can present with lower leg hemorrhagic bullae, purpura, and skin necrosis. Aeromonas hydrophila infection, in contrast to infection with V vulnificus, is marked by more myonecrosis and a distinctive foul odor when the wound is debrided. Most patients with A hydrophila had exposure to wet soil or dirty ditches.
Patients with necrotizing fasciitis are acutely ill. They are often thought to have cellulitis that is not responding to standard antibiotic therapy. There is commonly a paucity of cutaneous findings in the early course of the disease. Pain is out of proportion to physical findings. There may be associated skin necrosis and bullae formation. While necrotizing fasciitis most commonly involves the lower extremities, other sites may also be involved. Signs of systemic illness such as fever, lethargy, hypotension, and tachycardia are present; these may progress to multiorgan failure.
The mortality of necrotizing fasciitis is high. Treatment includes broad-spectrum intravenous (IV) antibiotics and immediate surgical debridement of infected and devitalized tissue. Therefore, if you are considering this diagnosis, stop reading this and contact a surgeon now.
When necrotizing fasciitis is localized to the lower abdominal wall, perineum, or genitals, it is known as Fournier gangrene. Diabetic patients are particularly susceptible to Fournier gangrene, which is often polymicrobial with mixed anaerobic organisms.
M72.6 – Necrotizing fasciitis
52486002 – Necrotizing fasciitis
- Subcutaneous acute febrile neutrophilic dermatosis (subcutaneous Sweet syndrome)
- Ecthyma gangrenosum
- Deep vein thrombosis
- Purpura fulminans complicating varicella
- Insect bite (eg, brown recluse spider)
- Disseminated intravascular coagulation
- Staphylococcal scalded skin syndrome
- Toxic shock syndrome
- Vibrio vulnificus infection
Last Updated: 05/13/2019