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Neurogenic ulcer
Other Resources UpToDate PubMed

Neurogenic ulcer

Contributors: Noah Craft MD, PhD, Lindy P. Fox MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed


Neurogenic ulcers (also known as neuropathic and diabetic ulcers; mal perforans) will affect approximately 15% of individuals with diabetes during their lifetime. The pathogenesis of these ulcers is multifactorial and has to do with peripheral vascular disease, peripheral neuropathy, repetitive trauma, and mechanical change in the bony architecture of the foot over time. They occur over pressure points on the feet of individuals who have had diabetes for many years.

While the overwhelming majority of neurogenic ulcers occur in individuals with diabetes, any condition resulting in polyneuropathy (alcohol use disorder, arsenic poisoning, etc) or local neuropathy (eg, herpes zoster, Hansen disease) will predispose an individual to their formation.

Neurogenic ulcers are difficult to treat, frequently recur, and result in significant morbidity in the form of loss of function and, often, loss of limb.


E13.621 – Other specified diabetes mellitus with foot ulcer

15074003 – Neurogenic ulcer

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Keep in mind that many conditions that lead to skin ulceration may coexist within the same patient.

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Last Updated:12/04/2019
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Patient Information for Neurogenic ulcer
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Neurogenic ulcer
A medical illustration showing key findings of Neurogenic ulcer : Heel, Neuropathy peripheral, Skin ulcer, Foot or toes, Plantar foot
Clinical image of Neurogenic ulcer - imageId=88325. Click to open in gallery.  caption: 'An ulcerated hyperkeratotic plaque on the distal sole.'
An ulcerated hyperkeratotic plaque on the distal sole.
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