SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences

View all Images (8)

Neutrophilic eccrine hidradenitis in Child
Other Resources UpToDate PubMed

Neutrophilic eccrine hidradenitis in Child

Contributors: Vivian Wong MD, PhD, Susan Burgin MD
Other Resources UpToDate PubMed


Neutrophilic eccrine hidradenitis is a disorder characterized by toxic injury to eccrine coils resulting in erythematous or purpuric lesions on the trunk, limbs, neck, face, scalp, and/or ears. The disorder is most frequently associated with chemotherapy, but may be associated with other etiologies:
  • Predisposing medications, including cytarabine, mitoxantrone, bleomycin, and other chemotherapy agents, but not limited to this class. Other triggers include acetaminophen, carbamazepine, and granulocyte colony-stimulating factor (G-CSF); this reaction typically occurs 8-10 days after initiation of the drug.
  • A paraneoplastic phenomenon, as it has been reported with myeloproliferative and lymphoproliferative malignancy as well as solid organ malignancies (such as osteosarcoma, testicular carcinoma, metastatic breast cancer, and Wilms tumor) without preceding chemotherapy.
  • Human immunodeficiency virus (HIV) and Behçet disease.
  • Rarely, with bacterial infection (Serratia, Staphylococcus, Enterobacter, and Nocardia).
Patients may present with fever, neutropenia, lesion pruritus, and pain and tenderness. Lesions are usually self-limited and rarely will recur with subsequent drug exposure.


L74.8 – Other eccrine sweat disorders

238754005 – Neutrophilic eccrine hidradenitis

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

  • Exanthematous drug eruption
  • Folliculitis
  • Pityrosporum folliculitis
  • Leukemia cutis
  • Acute febrile neutrophilic dermatosis
  • Arthropod bite or sting (insect bites)
  • Erythema elevatum diutinum
  • Toxic erythema of chemotherapy
  • Cellulitis

Best Tests

Subscription Required

Management Pearls

Subscription Required


Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required


Subscription Required

Last Reviewed:08/05/2018
Last Updated:09/11/2018
Copyright © 2024 VisualDx®. All rights reserved.
Neutrophilic eccrine hidradenitis in Child
A medical illustration showing key findings of Neutrophilic eccrine hidradenitis : Tender skin lesion, Widespread distribution, Smooth nodules
Clinical image of Neutrophilic eccrine hidradenitis - imageId=3839. Click to open in gallery.  caption: 'A close-up of showers of small erythematous papules.'
A close-up of showers of small erythematous papules.
Copyright © 2024 VisualDx®. All rights reserved.