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Nevus comedonicus in Infant/Neonate
Other Resources UpToDate PubMed

Nevus comedonicus in Infant/Neonate

Contributors: Maressa Criscito MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Nevus comedonicus (NC) is a rare type of organoid epidermal nevus that presents with dilated follicular openings filled with keratinous plugs. While NC is considered an epidermal nevus derived from the hair follicle, it may also represent a hamartoma arising from the pilosebaceous unit. Genetic mosaicism may be involved in the pathogenesis of NC, and mutations in NEK9 and fibroblast growth factor receptor 2 (FGFR2) have been identified.

Approximately one-half of cases are present at birth, with most other cases appearing by 10-15 years of age. Rarely does it present in adulthood. Lesions generally present on the face, neck, upper arms, chest, and abdomen. NC is asymptomatic, and growth usually occurs during puberty. Two subtypes exist: a nonpyogenic type and a type associated with the formation of cysts, pustules, and abscesses. NC lesions may be complicated by large cysts, bacterial superinfection, chronic inflammation, and scarring.

NC syndrome refers to NC presenting in combination with extracutaneous manifestations, which may include central nervous and skeletal system anomalies as well as abnormalities associated with teeth and eyes, most commonly cataracts.

Codes

ICD10CM:
Q82.5 – Congenital non-neoplastic nevus

SNOMEDCT:
35962006 – Nevus comedonicus

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Last Reviewed:10/14/2019
Last Updated:01/20/2022
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Nevus comedonicus in Infant/Neonate
A medical illustration showing key findings of Nevus comedonicus : Face, Neck, Present at birth, Trunk, Upper arms
Clinical image of Nevus comedonicus - imageId=753599. Click to open in gallery.  caption: 'A close-up of groups of comedone-like pits of varying sizes and some tiny white papules.'
A close-up of groups of comedone-like pits of varying sizes and some tiny white papules.
Copyright © 2024 VisualDx®. All rights reserved.