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Nodular hidradenoma
Other Resources UpToDate PubMed

Nodular hidradenoma

Contributors: Karyn Alana Haitz BA, Susan Burgin MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Nodular hidradenoma is a rare, benign adnexal tumor that displays apocrine differentiation in the majority of cases (clear cell hidradenoma) and eccrine differentiation (poroid hidradenoma) in the remainder. The two histopathologic types are indistinguishable clinically. A 0.5-3 cm firm nodule develops on the head, anterior trunk, or upper limbs, or any other cutaneous site less frequently. It grows slowly and may ulcerate.

Nodular hidradenoma is more common in females and can occur in any ethnicity and at any age including infancy, although it is most common in the fourth decade of life. There are currently no known risk factors. Local recurrence can also occur, especially with inadequate surgical excision.

Hidradenocarcinoma (also known as malignant nodular hidradenoma [MNH]) is a very rare malignant tumor that can arise from nodular hidradenoma, although it typically arises de novo.

Codes

ICD10CM:
D23.9 – Other benign neoplasm of skin, unspecified

SNOMEDCT:
253020008 – Hidradenoma of skin

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Nodular basal cell carcinoma
  • Cutaneous squamous cell carcinoma
  • Hidradenocarcinoma – Typically larger than nodular hidradenomas and asymmetric in configuration. Hidradenocarcinomas usually are seen in the sixth to seventh decade of life. They grow slowly and may or may not be ulcerated.
  • Eccrine poroma
  • Metastatic Renal cell carcinoma
  • Glomus tumor

Best Tests

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Management Pearls

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Therapy

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References

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Last Updated:06/01/2023
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Nodular hidradenoma
A medical illustration showing key findings of Nodular hidradenoma : Smooth nodule
Clinical image of Nodular hidradenoma - imageId=6051125. Click to open in gallery.  caption: 'A close-up of a reddish-blue translucent nodule with overlying telangiectasias.'
A close-up of a reddish-blue translucent nodule with overlying telangiectasias.
Copyright © 2024 VisualDx®. All rights reserved.