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Ofuji disease
Other Resources UpToDate PubMed

Ofuji disease

Contributors: Ricardo Guerra, Susan Burgin MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed


Ofuji disease, or classic eosinophilic pustular folliculitis (EPF), is an inflammatory folliculitis characterized by sterile follicular pustule formation.

Classical EPF is more common in immunocompetent individuals in Japan and has a slight male predominance with peak incidence around the age of 30. Recurrent crops of follicular papular pustules arise on normal skin and atop erythematous plaques. There is typically intense accompanying pruritus. The lesions often heal in 7-10 days and reappear every 3-4 weeks. The face and trunk are commonly affected, but other variants can affect the extremities, palms, and soles. Systemic symptoms are not usually seen.

The etiology of classic EPF remains unclear. Some evidence suggests involvement of cytokines and adhesion molecules that activate the follicular unit.


L73.8 – Other specified follicular disorders

95333004 – Eosinophilic pustular folliculitis

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Differential Diagnosis & Pitfalls

  • Immunosuppression-associated eosinophilic folliculitis – Discrete urticarial follicular papules with more severe pruritus refractory to indomethacin treatment in an immunosuppressed individual.
  • Eosinophilic pustular folliculitis in infancy – Patients are usually between 2-10 months of age with papulopustular lesions on the scalp and no annular pattern. 
  • Bacterial Folliculitis
  • Pityrosporum folliculitis
  • Demodex folliculitis
  • Acne vulgaris
  • Rosacea
  • Perioral dermatitis
  • Amicrobial pustulosis of the folds
  • IgA pemphigus
  • Subcorneal pustular dermatosis – Annular lesions with sterile pustules never affecting the face.
  • Miliaria pustulosa
  • Tinea faciei – Typically annular scaly plaques are seen; pustules are uncommon. 
  • Palmoplantar pustulosis

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Last Reviewed:09/17/2017
Last Updated:10/05/2017
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Ofuji disease
A medical illustration showing key findings of Ofuji disease : Face, Trunk, Pruritus, Erythematous plaques, Leukocyte count increased, Eosinophil count increased
Copyright © 2024 VisualDx®. All rights reserved.