Oral fibroma - Oral Mucosal Lesion
The patient notices a painless (unless recently bitten) nodule that is located at sites easily bitten, such as the lower labial mucosa, lateral tongue, and buccal mucosa.
D10.30 – Benign neoplasm of unspecified part of mouth
128046007 – Disease of oral mucosa
Differential Diagnosis & Pitfalls
- Lipoma – These are generally yellow, but some contain more fibrous tissue and appear pink.
- Oral papilloma
- Granular cell tumor
- Benign salivary gland tumor – These tend to be more firm and somewhat more deep-seated.
- Malignant salivary gland tumor
- Lobular capillary hemangioma (pyogenic granuloma) – Tends to be reddish-purple in color.
- Soft tissue tumors (eg, neural tumors)
- Medication-associated fibrous nodules – Occur in patients on cyclosporine after allogenic hematopoietic stem cell transplantation.
- Mucocele – Dome-shaped, bluish, and fluid-filled, but they may become sclerosed, organized, and fibrotic over time.
- Giant cell fibroma – A histologic variant, it has a papillary rather than smooth surface and is located mainly on the gingiva, tongue, and palate.
- Cowden syndrome – Presents with not solitary but multiple fibrous nodules and papules in the oral mucosa with typical concomitant skin tumors.