Oral leukemic infiltration - Oral Mucosal Lesion
Patients report weight loss, fatigue, loss of appetite, and easy bruisability. The infiltrate often develops over weeks and months.
C95.90 – Leukemia, unspecified not having achieved remission
404156009 – Leukemic infiltration of skin
Differential Diagnosis & Pitfalls
- Gingival hyperplasia caused by poor oral hygiene is associated with a healthy individual with no change in health status (unless it is pregnancy or puberty associated).
- Gingival hyperplasia caused by ingestion of medications is seen in patients with specific medical histories such as seizure disorders, organ transplantation, and hypertension. Hereditary gingival hyperplasia has an associated family history of this disorder, and the gingival growth is present from childhood. It has a pink or fibrotic appearance with a firm texture.
- Juvenile hyaline fibromatosis is associated with skin lesions.
- Orofacial granulomatosis exhibits gingival hyperplasia that tends to be somewhat firm and fibrotic and is associated with recurrent or concomitant orofacial swelling.
- Granulomatosis with polyangiitis may have a similar gingival appearance, and the patient may also have upper respiratory signs, evidence of kidney disease, or elevated p-ANCA and c-ANCA levels.
- Kaposi sarcoma is purplish/blue/red and has typical biopsy findings.
- Ligneous gingivitis has typical biopsy findings and a history of plasminogen deficiency.
- Scurvy (vitamin C deficiency)
- Langerhans cell histiocytosis
- Oral exostoses