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Oral papilloma - Oral Mucosal Lesion
Other Resources UpToDate PubMed

Oral papilloma - Oral Mucosal Lesion

Contributors: Rajini Murthy MD, Carl Allen DDS, MSD, Sook-Bin Woo MS, DMD, MMSc, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Oral papilloma is also known as squamous papilloma caused by human papillomavirus (HPV). It presents as a slow-growing, cauliflower-like lesion in the oral cavity. Oral papilloma occurs in about 1 of every 250 adults, most often during the third to fifth decades. It also accounts for 8% of oral tumors in children. Virus subtypes 6 and 11 have been identified in 50% of these lesions. The mode of transmission is unknown, but the viruses in this condition appear to have low virulence and infectivity rate. Any oral surface can be affected, but it most commonly appears on the tongue, lips, and soft palate.

Codes

ICD10CM:
B07.8 – Other viral warts
D10.30 – Benign neoplasm of unspecified part of mouth

SNOMEDCT:
402908003 – Oral wart

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Common wart – Often arises in children on the vermillion or on the labial mucosa. Cutaneous warts are often present as well. Caused by HPV types 2 and 4.
  • Oral mucosal wart – Condyloma is considered a sexually transmitted disease caused by one of several strains of HPV, with lesions developing at the site of sexual contact. They are usually sessile, pink, have blunted projections, are larger than papillomas, and often are multiple.
  • Verruciform xanthoma – An uncommon benign lesion is typically seen on the gingiva or alveolar mucosa and may have a yellowish tinge.
  • Oral mucosal wart – Multiple flattened or rounded papules, typically with the same color as the surrounding mucosa. More common in children, particularly indigenous populations. Caused by HPV types 13 and 32. Focal epithelial hyperplasia-like lesions have also been described in HIV-infected patients.
  • Oral fibroma

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:01/01/2024
Last Updated:01/11/2024
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Oral papilloma - Oral Mucosal Lesion
A medical illustration showing key findings of Oral papilloma : Dorsal tongue, Gingival-alveolar mucosa, Soft palate/tonsillar
Clinical image of Oral papilloma - imageId=2487516. Click to open in gallery.  caption: 'A pink and whitish verrucous papule on the ventral tongue.'
A pink and whitish verrucous papule on the ventral tongue.
Copyright © 2024 VisualDx®. All rights reserved.