Oral melanotic macule - Oral Mucosal Lesion
D10.30 – Benign neoplasm of unspecified part of mouth
403449001 – Melanotic macule of oral mucosa (reactive type)
- Amalgam tattoo (exogenous pigmentation) – This is the most common intraoral pigmented lesion. Usually the amalgam tattoo is not elevated and particles of dental amalgam (silver filling material) can often be detected on periapical radiographs of the lesional site.
- Melanoacanthoma – This uncommon condition occurs most frequently in young adult African-American woman, typically on the buccal mucosa. The lesion is generally much larger (1 cm or greater) than a melanocytic nevus, and it often follows a characteristic pattern of spontaneous involution over a period of days to weeks.
- Melanoma (primary or metastatic) – Both primary and metastatic melanoma are rarely seen intraorally, and in their earliest phases could be mistaken for melanocytic nevus.
- Nevus or blue nevus
- Varix (venous lake) is a common lesion on the lower vermilion, but this tends to be a papule or bleb that blanches if pressure is applied to it. It also tends to occur in older adults.
- Smoker's melanosis tends to be located on the anterior mandibular buccal attached gingiva in a bilaterally symmetric distribution.
- Peutz-Jeghers syndrome
- Carney complex
- LEOPARD syndrome
- Drug-induced pigmentation / drug-induced oral pigmentation (eg, antimalarials, tetracyclines, some chemotherapeutic agents)
- Heavy metal poisoning (see arsenic poisoning, lead poisoning, mercury poisoning, thallium poisoning)
- Addison disease
- Kaposi sarcoma
- Albright syndrome
- Laugier-Hunziker syndrome