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Paget disease of bone
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Paget disease of bone

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Contributors: Joon B. Kim BS, Pamela L. Sloan MD, Benjamin L. Mazer MD, MBA, Abhijeet Waghray MD
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Synopsis

Paget disease is caused by increased bone remodeling and focal bone growth. It is a disease of osteoclasts that is generally seen in older adults and typically affects the skull, spine, pelvis, and long bones of the lower extremities. A common finding associated with aging, Paget disease is identified in 2%-9% of elderly patients, with age of onset at 55 years.

The disease is often asymptomatic but can cause bone pain, fractures, bone deformity, and symptoms due to compression of surrounding structures (eg, hearing loss, lumbar radicular pain). Genetics and viruses are suspected to play a role in causing the disease.

Bisphosphonates are used to treat the disease.

Codes

ICD10CM:
M88.9 – Osteitis deformans of unspecified bone

SNOMEDCT:
2089002 – Osteitis deformans

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Therapy

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References

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Last Reviewed: 02/07/2019
Last Updated: 02/25/2019
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Paget disease of bone
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Paget disease of bone : Headache, Bone pain, Hearing loss, Lytic bone lesions, Arthralgia
Imaging Studies image of Paget disease of bone
Cortical and trabecular thickening and sclerosis with an expanded appearance of the middle finger metacarpal compatible with Paget disease.
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