Paget disease of bone
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Synopsis
Paget disease is caused by increased bone remodeling and focal bone growth. It is a disease of osteoclasts that is generally seen in older adults and typically affects the skull, spine, pelvis, and long bones of the lower extremities. A common finding associated with aging, Paget disease is identified in 2%-9% of elderly patients, with age of onset at 55 years.The disease is often asymptomatic but can cause bone pain, fractures, bone deformity, and symptoms due to compression of surrounding structures (eg, hearing loss, lumbar radicular pain). Genetics and viruses are suspected to play a role in causing the disease.
Bisphosphonates are used to treat the disease.
Codes
ICD10CM:M88.9 – Osteitis deformans of unspecified bone
SNOMEDCT:
2089002 – Osteitis deformans
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Osteoarthritis
- Osteoporosis
- Malignancy (particularly metastasis to bone, primary bone, multiple myeloma)
- Renal osteodystrophy
- Fibrous dysplasia
- Hyperparathyroidism
- Fibrogenesis imperfecta ossium
- Hyperthyroidism
- Hypercalcemia
- Gaucher disease
Best Tests
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Management Pearls
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Therapy
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References
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Last Reviewed:02/06/2019
Last Updated:02/24/2019
Last Updated:02/24/2019
Paget disease of bone