Peptic ulcer disease
Alerts and Notices
Synopsis

The primary complications of peptic ulcers are acute bleeding with blood loss anemia and perforation due to ulcer erosion through the mucosal wall. These complications require either endoscopic or surgical intervention.
Codes
ICD10CM:K27.9 – Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation
SNOMEDCT:
13200003 – Peptic ulcer
Look For
Subscription Required
Diagnostic Pearls
Subscription Required
Differential Diagnosis & Pitfalls
- Gastritis
- Acute coronary syndrome
- Coronary artery disease
- Esophagitis
- Esophageal spasm (see esophageal motility disorder)
- Gastroparesis
- Hiatal hernia
- Gastroenteritis
- Mesenteric ischemia
- Inflammatory bowel disease (ulcerative colitis, Crohn disease)
- Malignancy (particularly esophageal, gastric, small bowel, and pancreatic)
- Biliary colic / cholelithiasis
- Zollinger-Ellison syndrome
- Celiac disease
- Tropical sprue
- Chronic pancreatitis
- Drug side effects (NSAIDs, alcohol, caffeine, antibiotics, corticosteroids, opiates, digoxin)
- Irritable bowel syndrome
Best Tests
Subscription Required
Management Pearls
Subscription Required
Therapy
Subscription Required
Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
Subscription Required
Last Reviewed:09/25/2017
Last Updated:07/06/2021
Last Updated:07/06/2021