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Perioral dermatitis of childhood in Child
Other Resources UpToDate PubMed

Perioral dermatitis of childhood in Child

Contributors: Connie R. Shi MD, Susan Burgin MD
Other Resources UpToDate PubMed


This summary addresses perioral dermatitis in children. Perioral dermatitis in adults is addressed separately.

Perioral dermatitis (also called periorificial dermatitis) is a benign inflammatory eruption characterized by erythematous papules and pustules around the mouth. The eruption may also involve periorbital and perinasal areas. Lesions are typically asymptomatic but may be mildly pruritic.

Childhood granulomatous periorificial dermatitis (CGPD) is an uncommon granulomatous variant of perioral dermatitis. CGPD predominantly affects prepubertal children and is thought to be more common among individuals with darker skin phototypes, although cases have been reported in individuals with lighter phototypes as well. CGPD may be mildly pruritic and may wax and wane for years.

Development of perioral dermatitis is often preceded by exposure to topical corticosteroids on the face. Inhaled and systemic corticosteroids have also been associated with perioral dermatitis. Various cosmetic products, including fluorinated toothpastes, have also been reported as potential precipitants of this condition.


L71.0 – Perioral dermatitis

238751002 – Perioral dermatitis

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Allergic contact dermatitis
  • Atopic dermatitis
  • Acne vulgaris
  • Lip-licking dermatitis
  • Seborrheic dermatitis
  • Hereditary acrodermatitis enteropathica (infants)
  • Rosacea (uncommon in children)
  • Sarcoidosis (uncommon in children)
  • Lupus miliaris disseminatus faciei (uncommon in children)

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Reviewed:11/17/2016
Last Updated:11/17/2016
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Perioral dermatitis of childhood in Child
A medical illustration showing key findings of Perioral dermatitis of childhood : Eyelids, Perioral, Smooth papules, Cheeks
Clinical image of Perioral dermatitis of childhood - imageId=1172467. Click to open in gallery.  caption: 'Numerous substantive pink papules around the mouth.'
Numerous substantive pink papules around the mouth.
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