Postural orthostatic tachycardia syndrome (POTS) is a condition of orthostatic dysregulation. The hallmark of POTS is an aberrant autonomic response occurring in an upright posture and resulting in orthostatic intolerance. Patients clinically experience dizziness, lightheadedness, blurring of vision, palpitations, fatigue, and/or generalized weakness. Patients with POTS will experience these symptoms along with tachycardia, although they will not have arterial hypotension.

POTS tends to affect younger patients (most often those younger than 50 years) and has a strong predilection for women (5:1 compared with men). It often occurs following a viral infection, including SARS-CoV-2 / COVID-19 (see also post-COVID conditions). Most patients will improve over time with treatment or spontaneously, although many experience chronic symptoms. POTS does not affect mortality.