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Primary ovarian insufficiency
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Primary ovarian insufficiency

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Contributors: Mitchell Linder MD
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Synopsis

Primary ovarian insufficiency (POI), also known as premature ovarian failure, describes a pathologic condition that occurs when the hypothalamic-pituitary-gonadal axis stops functioning earlier than it should. Historically, the cut-off age between having these changes associated with perimenopause / menopause versus having them associated with POI has been 40.

The pathophysiology of POI is related to decreasing follicles (low starting amount versus increased destruction) and/or poor follicular response to gonadotrophins. The etiology for POI is unknown in the majority of cases but may be related to injury to ovarian tissue caused by surgery, chemotherapy, autoimmune processes, or radiation. There is evidence of a genetic component to this condition; underlying fragile X syndrome or Turner syndrome can also cause POI.

Patients can present with a variety of complaints, but the most common presentation is absence or decreased frequency of menses. Other symptoms may include vasomotor symptoms, mood changes, vaginal dryness, recurrent miscarriage, or inability to become pregnant.

For more information, see OMIM.

Codes

ICD10CM:
E28.39 – Other primary ovarian failure

SNOMEDCT:
237788002 – Premature ovarian failure

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 12/29/2017
Last Updated: 12/29/2017
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Primary ovarian insufficiency
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Primary ovarian insufficiency : Amenorrhea, Infertility, Oligomenorrhea
Copyright © 2019 VisualDx®. All rights reserved.